Dental Care Bones are the only chews on the market that contain the 100% natural and clinically proven kelp ingredient A.N ProDen®. Dental Care Bones help oral problems with double action – ProDen PlaqueOff System™ and the bone’s unique shape helps to prevent new plaque and tartar from forming when used as directed, resulting in a fresher breath. They also contain omega 3 and 6 fatty acids and antioxidants that support immune health. The Chicken & Pumpkin flavor is suitable for sensitive stomachs and is the perfect reward for your dog to relax with. The Dental Care Bones contain 13 bones per bag and the dosage for dogs 50 lbs. or greater is one bone daily. For the smaller dogs, our Dental Care Bones are perfect to break in half for daily dosage. Dogs having problems with the thyroid gland must be careful with their intake of iodine. Since kelp, including our unique ingredient, have a naturally high iodine content, we do not recommend that dogs with thyroid problems use this product. Store in a cool, dry place.